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  Indian J Med Microbiol
 

Figure 1: Chemical formula of reference drugs and designed synthetic compounds for evaluating in vitro anti-plasmodial activity. The quinoline, quinazoline, and acridine rings from reference drugs and active moiety of (5-nitroheteroaryl) methylene hydrazine, inspired from nitrofurantoin and nifurtimox, were used to design and synthesize six new derivatives (1a, 1b, 2a, 2b, 3a, and 3b). 1a: 1-(7-chloroquinolin-4-yl)-2-((5-nitrofuran-2-yl) methylene) hydrazine; 1b: 1-(7-chloroquinolin-4-yl)-2-((5-nitrothiophene-2-yl)methylene) hydrazine; 2a: 1-(quinazolin-4-yl)-2-((5-nitrofuran-2-yl) methylene)hydrazine; 2b: 1-(quinazolin-4-yl)-2-((5-nitrothiophen-2-yl)methylene)hydrazine; 3a: 1-(6-chloro-2-methoxyacridine-9-yl)-2-((5-nitrofuran-2- yl)methylene) hydrazine; 3b: 1-(6-chloro-2-methoxyacridine-9-yl)-2-((5-nitrothiophene-2-yl)methylene) hydrazine.

Figure 1: Chemical formula of reference drugs and designed synthetic compounds for evaluating <i>in vitro</i> anti-plasmodial activity. The quinoline, quinazoline, and acridine rings from reference drugs and active moiety of (5-nitroheteroaryl) methylene hydrazine, inspired from nitrofurantoin and nifurtimox, were used to design and synthesize six new derivatives (<b>1a, 1b, 2a, 2b, 3a</b>, and <b>3b</b>). <b>1a</b>: 1-(7-chloroquinolin-4-yl)-2-((5-nitrofuran-2-yl) methylene) hydrazine; <b>1b</b>: 1-(7-chloroquinolin-4-yl)-2-((5-nitrothiophene-2-yl)methylene) hydrazine; <b>2a</b>: 1-(quinazolin-4-yl)-2-((5-nitrofuran-2-yl) methylene)hydrazine; <b>2b</b>: 1-(quinazolin-4-yl)-2-((5-nitrothiophen-2-yl)methylene)hydrazine; <b>3a</b>: 1-(6-chloro-2-methoxyacridine-9-yl)-2-((5-nitrofuran-2- yl)methylene) hydrazine; <b>3b</b>: 1-(6-chloro-2-methoxyacridine-9-yl)-2-((5-nitrothiophene-2-yl)methylene) hydrazine.