Figure 2: Histological sections of skin in the L. major infected BALB/c. Treated by voriconazole (D) for 28 days, compare to the glucantime (C) and vehicle (B) treated and the untreated (A) groups (H & E, ×400). Necrotic area (N) and number of macrophages (yellow arrow), neutrophils (white arrow) and amastigotes (black arrow) decreased in the voriconazole and glucantime groups. Presence of fibroblasts (red arrow) and neovascularization in depth of ulcers in the mice treated by voriconazole and glucantime indicated improved granulation tissue formation in the lesions of these therapeutic regimens.