Asian Pacific Journal of Tropical Medicine

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 14  |  Issue : 2  |  Page : 64--72

Genomic characterization of velogenic avian orthoavulavirus 1 isolates from poultry workers: Implications to emergence and its zoonotic potential towards public health


Muhammad Zubair Shabbir1, Ruth Helmus Nissly2, Abdul Ahad3, Masood Rabbani1, Levina Lim2, Shubhada K Chothe2, Murugan Subbiah2, Aswathy Sebastian4, Istvan Albert4, Aziz Ul-Rahman5, Bhushan M Jayarao2, Suresh V Kuchipudi2 
1 University of Veterinary and Animal Sciences, Lahore, Pakistan
2 Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA
3 Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh
4 Bioinformatics Consulting Center, The Pennsylvania State University, University Park, Pennsylvania, USA
5 Department of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan

Correspondence Address:
Suresh V Kuchipudi
Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania
USA

Objective: To carry out the genetic characterization and evolutionary analysis of three avian orthoavulavirus 1 (AOAV-1) isolates from poultry workers with respiratory symptoms. Methods: Using Illumina MiSeq, whole-genome sequencing was carried out to assess the evolutionary dynamics of three AOAV-1 isolates. A phylogenetic and comparative analysis of all coding genes was done using bioinformatics tools. Results: Phylogenetic analysis and genetic distance estimation suggested a close relationship among human- and avian-originated velogenic strains of genotype XIII, sub-genotype XIII.2.1. Several substitutions in the significant structural and biological motifs were exclusively identified in the human-originated strains. Conclusions: To our knowledge, this is the first report of a velogenic AOAV-1 isolate from natural infection of the human upper respiratory tract. Our findings highlight the evolution and zoonotic potential of velogenic AOAV-1 in a disease endemic setting.


How to cite this article:
Shabbir MZ, Nissly RH, Ahad A, Rabbani M, Lim L, Chothe SK, Subbiah M, Sebastian A, Albert I, Ul-Rahman A, Jayarao BM, Kuchipudi SV. Genomic characterization of velogenic avian orthoavulavirus 1 isolates from poultry workers: Implications to emergence and its zoonotic potential towards public health.Asian Pac J Trop Med 2021;14:64-72


How to cite this URL:
Shabbir MZ, Nissly RH, Ahad A, Rabbani M, Lim L, Chothe SK, Subbiah M, Sebastian A, Albert I, Ul-Rahman A, Jayarao BM, Kuchipudi SV. Genomic characterization of velogenic avian orthoavulavirus 1 isolates from poultry workers: Implications to emergence and its zoonotic potential towards public health. Asian Pac J Trop Med [serial online] 2021 [cited 2023 Feb 7 ];14:64-72
Available from: https://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=2;spage=64;epage=72;aulast=Shabbir;type=0