Asian Pacific Journal of Tropical Medicine

REVIEW ARTICLE
Year
: 2021  |  Volume : 14  |  Issue : 1  |  Page : 5--9

Gender disparity in COVID-19: Role of sex steroid hormones


Anuja Lipsa, Jyothi S Prabhu 
 St Johns Research Institute and St Johns Medical College, St Johns National Academy of Health Sciences, Bangalore-560034. Karnataka, India

Correspondence Address:
Jyothi S Prabhu
St Johns Research Institute and St Johns Medical College, St Johns National Academy of Health Sciences, Bangalore-560034. Karnataka
India

The emerging pandemic of COVID-19 caused by the novel pathogenic human coronavirus SARS-CoV-2 has caused significant morbidity and mortality across the globe, prompting the scientific world to search for preventive measures to interrupt the disease process. Demographic data indicates gender-based differences in COVID-19 morbidity with better outcome amongst females. Disparity in sex-dependent morbidity and mortality in COVID-19 patients may be attributed to difference in levels of sex steroid hormones -androgens and estrogens. Evidence suggests that apart from the regulation of viral host factors, immunomodulatory and cardioprotective roles exerted by estrogen and progesterone may provide protection to females against COVID-19. Exploring the underlying mechanisms and beneficial effects of these hormones as an adjuvant to existing therapy may be a step towards improving the outcomes. This article aims to review studies demonstrating the role of sex steroidal hormones in modulating SARS-CoV-2 host factors and summarize plausible biological reasons for sex-based differences seen in COVID-19 mortality.


How to cite this article:
Lipsa A, Prabhu JS. Gender disparity in COVID-19: Role of sex steroid hormones.Asian Pac J Trop Med 2021;14:5-9


How to cite this URL:
Lipsa A, Prabhu JS. Gender disparity in COVID-19: Role of sex steroid hormones. Asian Pac J Trop Med [serial online] 2021 [cited 2021 Jan 21 ];14:5-9
Available from: https://www.apjtm.org/article.asp?issn=1995-7645;year=2021;volume=14;issue=1;spage=5;epage=9;aulast=Lipsa;type=0