Asian Pacific Journal of Tropical Medicine

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 11  |  Issue : 6  |  Page : 376--380

Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) polymorphism as a genetic marker of cerebral malaria in Thai population


Saw Thu Wah1, Hathairad Hananantachai2, Jintana Patarapotikul2, Jun Ohashi3, Izumi Naka3, Pornlada Nuchnoi4 
1 Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Department of Medical Laboratory Technology, University of Medical Technology, Yangon 11012, Myanmar
2 Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
3 Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan
4 Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University; Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand

Correspondence Address:
Dr. Pornlada Nuchnoi
Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok 10700
Thailand

Objective: To know whether the effect of interferon-induced protein with tetratricopeptide repeats (IFIT) 1 polymorphism influences the susceptibility of cerebral malaria outcome. Methods: Case-control association study was performed among 314 Thai patients (110 with cerebral malaria and 204 with uncomplicated malaria) infected with Plasmodium falciparum. Genotyping for five tag-single nucleotide polymorphisms of IFIT1 was performed by endpoint genotyping. Results: Genotype frequencies of all tag-SNPs (single nucleotide polymorphisms) showed no association with malaria outcome. However, C allele of rs11203109 was associated with the protection from cerebral malaria (OR=0.62, 95% CI=0.38-0.99, P=0.048). Two single nucleotide polymorphisms (rs5786868 and rs57941432) were in linkage disequilibrium with rs11203109. Conclusions: This suggests that our associated single nucleotide polymorphism (rs11203109) might be a genetic marker of cerebral malaria progression in the Thai population.


How to cite this article:
Wah ST, Hananantachai H, Patarapotikul J, Ohashi J, Naka I, Nuchnoi P. Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) polymorphism as a genetic marker of cerebral malaria in Thai population.Asian Pac J Trop Med 2018;11:376-380


How to cite this URL:
Wah ST, Hananantachai H, Patarapotikul J, Ohashi J, Naka I, Nuchnoi P. Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) polymorphism as a genetic marker of cerebral malaria in Thai population. Asian Pac J Trop Med [serial online] 2018 [cited 2021 Apr 13 ];11:376-380
Available from: https://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=6;spage=376;epage=380;aulast=Wah;type=0