Asian Pacific Journal of Tropical Medicine

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 11  |  Issue : 3  |  Page : 202--208

Nacre extract prevents scopolamine-induced memory deficits in rodents


Tatsuya Fuji, Tatsurou Inoue, Yasushi Hasegawa 
 College of Environmental Technology, Muroran Institute of Technology, 27-1 Mizumoto, Muroran 050-8585, Japan

Correspondence Address:
Yasushi Hasegawa
College of Environmental Technology, Muroran Institute of Technology, 27-1 Mizumoto, Muroran 050-8585
Japan

Objective: To investigate whether the extract from the nacreous layer of pearl oysters (nacre extract) improves impairments in memory caused by scopolamine administration in rodents. Methods: Nacre extract was prepared from the inner shell layer of pearl oyster. Effects of nacre extract on scopolamine-induced memory impairment were estimated using novel object recognition test, Y-maze test, and Barnes maze test. Effect of nacre extract on mRNA expressions which are genes associated with memory in the hippocampus was investigated using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) analysis. Results: Administration of nacre extract led to the protection against scopolamine-induced impairments in object recognition, short-term memory, and spatial memory. Treatment with nacre extract reversed the mRNA expression of brain-derived neurotrophic factor (BDNF) and Homer protein homolog 1 (Homer-la) in the hippocampus, which decreased with the treatment of scopolamine. Conclusions: These results suggest that nacre extract has attenuating effects on memory impairments induced by scopolamine through the increase in mRNA expression of BDNF and Homer-1a.


How to cite this article:
Fuji T, Inoue T, Hasegawa Y. Nacre extract prevents scopolamine-induced memory deficits in rodents.Asian Pac J Trop Med 2018;11:202-208


How to cite this URL:
Fuji T, Inoue T, Hasegawa Y. Nacre extract prevents scopolamine-induced memory deficits in rodents. Asian Pac J Trop Med [serial online] 2018 [cited 2020 Oct 28 ];11:202-208
Available from: https://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=3;spage=202;epage=208;aulast=Fuji;type=0