Year : 2018 | Volume : 11 | Issue : 13 | Page : 28-
The first laboratory-confirmed SFTS case from the Xinjiang Uygur Autonomous Region importing to Hainan International Tourism Island
Li-ying Zhu1, Fei-fei Yin2, Abulimiti Moming3, Bo Wang1, Li-juan Gao4, Jian-wen Ruan4, Na Wu4, You Zhang2, Hua-lin Wang1, Zhi-hong Hu1, Gang Lu2, Fei Deng1, Shu Shen1,
1 State Key Laboratory of Virology, Microorganisms & Viruses Culture Collection Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
2 Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou, Hainan, and The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region; Department of Pathogen Biology, Hainan Medical University; Key Laboratory of Translational Tropical Medicine, Hainan Medical University, Haikou, Hainan, 571101, China
3 Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China
4 Department of Infectious Diseases, Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University, Haikou 570208, China
Severe fever with thrombocytopenia syndrome (SFTS) is an acute infectious disease caused by a tick-borne phlebovirus, which was reported to be continuously epidemic in Japan, Korea and in 23 provinces of China since 2010. Most laboratory-confirmed SFTS cases in China have been recorded in 18 Eastern and Central provinces. A few suspected cases with SFTS-like symptoms were reported to the Chinese Disease Prevention and Control Information System from provinces including Guangxi, Guangdong, Gansu and Xinjiang Uygur Autonomous Region (XJUAR), however diagnosis was not confrimed due to lack of molecular biological and virological evidence. Here we reported the first laboratory-confirmed SFTS case in 2017. A resident of Hainan International Tourism Island (HNITI) was bitten by ticks when traveling in XJUAR and had illness onset after returning to HNITI. RT-PCR detected SFTSV RNA in the patient’s serum samples. Antibodies against SFTSV were detected from the patient and the neutralization from serum samples was evaluated. And the samples of person who had close contact to the patient were also investigated. Moreover, a new SFTSV strain was isolated from the serum sample collected from the patient during acute phase of disease. The viral properties and phylogeny were further characterized. In addition, SFTSV was detected positive in ticks collected from XJUAR in 2017, which suggested that SFTSV was more widely distributed than we recognized. Therefore, this study identified the first SFTS case from XJUAR where confirmed cases have never been reported and demonstrated the substantial risk from SFTSV infection via tick bite there. It is also the first importing SFTS case in HNITI, which showed the significant role of human transport in disease spread and indicated that the recently authorized international tourism island may face more challenges for controlling other importing cases from different areas and countries.