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ORIGINAL ARTICLE
Year : 2020  |  Volume : 13  |  Issue : 12  |  Page : 566-572

In vitro efficacy of new synthetic benzimidazole-related compounds against Schistosoma mansoni adult worms


1 Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
2 Department of Medical Malacology, Theodor Bilharz Research Institute, Imbaba, Cairo, Egypt
3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa City, Mansoura, Egypt
4 Department of Biological Sciences and Biotechnology, Faculty of Science, The Hashemite University, Zarqa 13115, Jordan

Correspondence Address:
Amira Taman
Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura 35516
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-7645.296725

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Objective: To evaluate the in vitro antischistosomal activity of two new synthetic benzimidazole-related compounds: NBTP-OH and NBTP-F. Methods: Schistosoma adult worms were recovered from mice infected with Schistosoma mansoni cercaria, washed and then incubated in the culture media with different concentrations of compounds NBTP-OH and NBTP-F up to 72 h. Scanning electron microscopy was conducted to report morphological changes. Results: Incubation of adult Schistosoma mansoni with 10 μg/mL of NBTP-OH for 48 h killed 81.25% of worms. The calculated LC50 and LC90 72 h post-incubation were 6.8 μg/mL and 9.8 μg/ mL, respectively. Exposure of worms to 10 μg/mL of NBTP-F killed 89.5% of worms after 48 h, mostly males (83.3%), the LC50 and LC90 after 72 h of incubation were 4.8 μg/mL and 6.9 μg/mL, respectively. Worms incubated for 72 h with these compounds revealed swelling and deformity of oral sucker, disorganization and erosion of the tegument when examined with scanning electron microscopy. Conclusions: NBTP-OH and NBTP-F possess in vitro antischistosomal activities; however, in vivo studies should be conducted to examine their antischistosomal effects.


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