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REVIEW ARTICLE
Year : 2020  |  Volume : 13  |  Issue : 11  |  Page : 477-486

Convalescent plasma: A potential therapeutic option for COVID-19 patients


1 Biofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia
2 School of Biosciences, Faculty of Medical and Health Sciences, Taylor's University, Subang Jaya, Selangor, Malaysia
3 Faculty of Pharmacy, University of Cyberjaya, Cyberjaya, Selangor, Malaysia
4 PAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Brunei Darussalam
5 Biofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China

Correspondence Address:
Bey Hing Goh
Biofunctional Molecule Exploratory Research Group (BMEX), School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, P. R. China

Yin-Quan Tang
School of Biosciences, Faculty of Medical and Health Sciences, Taylor's University, Subang Jaya, Selangor
Malaysia
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Source of Support: The project is financially supported by Taylor’s University Emerging Grant (TRGS/ERFS/2/2018/SBS/016), Monash Global Asia in the 21st Century (GA21) research grants (GA-HW-19-L01 & GA-HW-19-S02), and Fundamental Research Grant Scheme (FRGS/1/2019/WAB09/MUSM/02/1 & FRGS/1/2019/SKK08/ TAYLOR/02/2). , Conflict of Interest: None


DOI: 10.4103/1995-7645.291408

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The new coronavirus disease (COVID-19) outbreak has challenged us to take unprecedented steps to bring this pandemic under control. In view of the urgency of this situation, convalescent plasma which was used in previous coronavirus outbreaks has emerged as one of the treatment options in this current pandemic. This is mainly due to the fact that convalescent plasma has been studied in a few case series with promising outcomes. In addition, on-going large clinical trials aimed to further evaluate the effectiveness, safety, and optimal dosage, duration and timing of administration of convalescent plasma are indeed revealing a certain level of promising results. Therefore, this article aims to provide an overview of possible mechanisms of actions of convalescent plasma, its benefits and its level of usage safeness by summarizing the existing evidence on the use of convalescent plasma in COVID-19 patients.


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