Impact Factor 2019: 1.940 (@Clarivate Analytics)
5-Year Impact Factor: 1.955 (@Clarivate Analytics)
  • Users Online: 37
  • Print this page
  • Email this page
SHORT COMMUNICATION
Year : 2020  |  Volume : 13  |  Issue : 10  |  Page : 464-466

Performance and correlation of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution


1 Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
2 Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
3 Biomed Diagnostics (Thailand) Co LTD, Bangkok, Thailand

Correspondence Address:
Kulkanya Chokephaibulkit
Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok
Thailand
Login to access the Email id

Source of Support: This study was supported by the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, [Grant Number (IO) R015832028)]. Oxford Immunotec and Biomed diagnostics (Thailand) provided the T-SPOT.TB test kit, Conflict of Interest: None


DOI: 10.4103/1995-7645.291040

Get Permissions

Objective: To evaluate the performance of interferon gamma release assays and tuberculin skin test in HIV-infected children and adolescents with immune reconstitution. Methods: A cross-sectional study was conducted in HIV-infected patients aged 5-18 years receiving antiretroviral treatment with CD4 T-lymphocytes >25% or >500 cells/mm3 for at least 6 months. QuantiFERON-TB Gold, T-SPOT.TB, and tuberculin skin test were performed in each patient. Results: A total of 50 patients were enrolled with median age of 13.7 years, CD4 counts of 753 (IQR: 587-989) cells/mm3. Among 27 patients with tuberculosis (16) or tuberculosis exposure (11), 8 (29.6%) were positive to at least one test, 2 (7.4%) were positive QuantiFERON-TB Gold, 3 (11.1%) positive T-SPOT.TB, and 7 (25.9%) had tuberculin skin test ≥5 mm. Among 23 patients without history of tuberculosis or exposure, all had negative interferon gamma release assays, while 2 (8.7%) had positive tuberculin skin test. Conclusions: All tests had low sensitivity despite immune reconstitution.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed178    
    Printed12    
    Emailed0    
    PDF Downloaded77    
    Comments [Add]    

Recommend this journal