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Table of Contents
PERSPECTIVE
Year : 2020  |  Volume : 13  |  Issue : 10  |  Page : 429-430

Insecticide resistance in Indian Anopheles: A stumbling block for malaria elimination


Division of Vector Borne Diseases, ICMR-National Institute of Research in Tribal Health, NIRTH Campus, Garha, Jabalpur, Madhya Pradesh, 482003, India

Date of Submission25-Mar-2020
Date of Decision06-Jul-2020
Date of Acceptance09-Jul-2020
Date of Web Publication14-Aug-2020

Correspondence Address:
Aparup Das
Division of Vector Borne Diseases, ICMR-National Institute of Research in Tribal Health, NIRTH Campus, Garha, Jabalpur, Madhya Pradesh, 482003
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-7645.291035

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How to cite this article:
Khan N, Mishra AK, Das A. Insecticide resistance in Indian Anopheles: A stumbling block for malaria elimination. Asian Pac J Trop Med 2020;13:429-30

How to cite this URL:
Khan N, Mishra AK, Das A. Insecticide resistance in Indian Anopheles: A stumbling block for malaria elimination. Asian Pac J Trop Med [serial online] 2020 [cited 2020 Nov 27];13:429-30. Available from: https://www.apjtm.org/text.asp?2020/13/10/429/291035

Malaria is a mosquito-borne disease caused by protozoan parasites of Plasmodium genus, inflicting health of human living in tropical and subtropical regions of the globe since time immemorial. India possesses highly diverged eco-climatic regions and rich biodiversity and is also highly endemic to malaria, contributing to about 87% of total cases in Southeast Asia and about 4% to the global malaria cases[1]. Although African countries contribute majorly to global malaria, malaria in India was considered to be highly complex due to several factors, including distribution of large varieties of species and subspecies of Anopheles mosquitoes adapted to different geographic locations[2]. For example, the malaria vector Anopheles (An.) culicifacies, mainly distributed in rural areas, is responsible for transmission of about 65% of total malaria cases and An. fluviatilis, distributed mainly in hilly forested areas, contributes to about 17% of total cases in India[3]. Other species distributed locally and focally, e.g., An. minimus and An. baimai (Northeastern states), An. sundaicus (Andaman and Nicobar Island) and An. stephensi (urban areas) transmit malaria in their respective confined areas of distribution. Apart from these six primary vectors of malaria, some secondary malaria vectors, e.g., An. annularis, An. subpictus, An. philippinensis and An. jeyporiensis also spread malaria to some extent in India[4].

During 1960s, simultaneous usage of dichlorodiphenyltrichloroethane (DDT) as insecticide in controlling malaria vectors and chloroquine as antimalarial treatment had brought down malaria incidences to a significant extent in India. This success, however, has been overshadowed by evolution and spread of resistance to DDT by Anopheles mosquitoes and to chloroquine by the malaria parasite Plasmodium falciparum at the global level including India. This had led to the World Health Organization and malaria control programs of endemic countries to deploy alternative insecticides and antimalarials. Although Stockholm Convention in 2004 had limited the use of DDT all over the globe in general, India still continues to use DDT for controlling vectors of both malaria and leishmaniasis[5]. While DDT is principally used as indoor residual spray (IRS), other chemicals (organophosphates, carbamate, pyrethroids etc.) are also in use for malaria control in India as adulticides[6]. Besides, another vector control method to prevent man-mosquito contact is the use of long lasting insecticide-treated bed net (LLIN) since 2009. In India, usage of IRS and LLINs are determined by annual parasite incidences in defined endemic localities. For example, areas with annual parasite incidences more than two get IRS and areas greater than five get LLINs as adulticides (http://.nvbdcp.gov.in). Although all these vector control measures have proven successful to a larger extent in contributing to decrease in malaria incidences in recent years in India, large scale usage of these chemicals in the field had contributed to emergence of mosquito vectors resistant to almost all the insecticides. A recent over 25 years meta-analysis of data on insecticide-resistant malaria vectors collected in 145 districts of 21 Indian states and two union territories indicates that An. culicifacies was resistant to at least one insecticide in 70% of the studied districts, mostly to DDT and malathion, justifying widespread resistance of An. culicifacies to multiple insecticides[7]. This, along with challenges in malaria diagnosis[8], widespread prevalence of chloroquine-resistant malaria parasite Plasmodium falciparum and artemisinin-resistant parasites knocking the Indian boarder[9] are daunting for targeted malaria elimination program by 2030 in India. In the absence of an effective malaria vaccine, constantly changing ecoclimatic factors and rapid urbanization in India creating new foci for vector breeding, and malaria elimination seems to be quite an uphill task.

Insects are considered to be the most successful organisms on earth, as they quickly evolve and efficiently adapt to new environmental conditions. On this line, as a measure of adaptation, Anopheles mosquitoes of India have evolved resistance to almost all the insecticides in use for vector control[10]. Considering vector control as the most effective way to malaria control/elimination and no new insecticides are planned for introduction into malaria control program in the near future, novel approaches must be adapted for controlling mosquito vector and thereby contributing to malaria elimination in India. To this respect, integrated vector management by improving efficacy, cost-effectiveness, ecological soundness and sustainability of vector control and introduction of new biological control ways could support the targeted elimination effort. Moreover, alternative methods of vector control, e.g., sustainable release of Anopheles mosquitoes incompetent of carrying malaria parasites (with Wolbachia-infected and employing gene-editing technologies) in malaria endemic locations could also be effective. Above all, community participation and ownership to different novel vector control measures could be the key to success to malaria elimination in India.

Conflict of interest statement

The authors declare that there is no conflict of interest.

Acknowledgements

The authors thank the Director General Indian Council of Medical Research, New Delhi for encouragements and support.

Authors’ contributions

N.K. collected information related to subject and wrote the initial version of the manuscript. A.K.M. helped in preparation of manuscript. A.D. conceptualized the idea and prepared the final version of the manuscript.

 
  References Top

1.
Das A, Anvikar AR, Cator LJ, Dhiman RC, Eapen A, Mishra N, et al. Malaria in India: The center for the study of complex malaria in India. Acta Trop 2012; 121: 267-273.  Back to cited text no. 1
    
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Singh V, Mishra N, Awasthi G, Dash AP, Das A. Why is it important to study malaria epidemiology in India? Trends Parasitol 2009; 25: 452-457.  Back to cited text no. 2
    
3.
Sahu SS, Gunasekaran K, Krishnamoorthy N, Vanamail P, Mathivanan A, Manonmani A, et al. Bionomics of Anopheles fluviatilis and Anopheles culicifacies (Diptera: Culicidae) in relation to malaria transmission in east- Central India. J Med Entomol 2017; 54: 821-830.  Back to cited text no. 3
    
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Dev V, Sharma VP. The dominant mosquito vectors of human malaria in India, Anopheles mosquitoes-new insights into malaria vectors. IntechOpen 2013; doi: 10.5772/55215.  Back to cited text no. 4
    
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Van Den Berg H, Manuweera G, Konradsen F. Global trends in the production and use of DDT for control of malaria and other vector-borne diseases. Malar J 2017; 16: 401.  Back to cited text no. 5
    
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Sharma SK, Upadhyay AK, Haque MA, Tyagi PK, Kindo BK. Impact of changing over of insecticide from synthetic pyrethroids to DDT for indoor residual spray in a malaria endemic area of Orissa, India. Ind J Med Res 2012; 135: 382.  Back to cited text no. 6
    
7.
Raghavendra K, Velamuri PS, Verma V, Elamathi N, Barik TK, Bhatt RM, et al. Temporo-spatial distribution of insecticide-resistance in Indian malaria vectors in the last quarter-century: Need for regular resistance monitoring and management. J Vector Borne Dis 2017; 54: 111-130.  Back to cited text no. 7
    
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Verma AK, Bharti PK, Das A. HRP-2 deletion: A hole in the ship of malaria elimination. Lancet Infect Dis 2018; 18: 826-827.  Back to cited text no. 8
    
9.
Cui L, Mharakurwa S, Ndiaye D, Rathod PK, Rosenthal PJ. Antimalarial drug resistance: Literature review and activities and findings of the ICEMR network. Am J Trop Med Hyg 2015; 93: 57-68.  Back to cited text no. 9
    
10.
Musa JJ, Moore SJ, Moore J, Mbuba E, Mbeyela E, Kobe D, et al. Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: A WHO-coordinated, prospective, international, observational cohort study. Lancet Infect Dis 2018; 18(6): 640-649.  Back to cited text no. 10
    




 

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