| ORIGINAL ARTICLE |
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| Year : 2018 | Volume
: 11
| Issue : 4 | Page : 292-296 |
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Pharmacological basis for the medicinal use of Michelia champaca in gut, airways and cardiovascular disorders
Fatima Saqib1, Zubia Mushtaq1, Khalid Hussain Janbaz1, Imran Imran1, Saikat Deawnjee2, Muhammad Zia-Ul-Haq3, Lorena Dima4
1 Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
2 Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
3 Office of Research, Innovation and Commercialization, Lahore College for Women University, Lahore 54600, Pakistan
4 Faculty of Medicine, Transilvania University of Brasov, Romania
Correspondence Address:
Muhammad Zia-Ul-Haq
Senior Manager Office of Research, Innovation and Commercialization, Lahore College for Women University, Lahore 54600
Pakistan
 Source of Support: None, Conflict of Interest: None  | 2 |
DOI: 10.4103/1995-7645.231470
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Objective: To discover the mechanism behind ameliorative effects of Michelia champaca (M. champaca) in gastrointestinal, respiratory and cardiovascular disorders. Methods: Anti- spasmodic potential was evaluated by trying the M. champaca extract (aqueous:ethanolic) on rabbit aorta, trachea and jejunum in vitro. Isotonic and isometric transducers coupled with Power Lab data acquisition system was used to record the responses of isolated tissues. Results: M. champaca extract relaxed the spontaneous and high K+ (80 mmol/L)-induced contractions of isolated jejunum preparation of rabbit showing a Ca2+ channel blocking mechanism. Moreover, extract shifted calcium concentration response curves towards right like standard calcium channel blocker verapamil. In rabbit tracheal preparation, M. champaca relaxed both carbachol (1 1 μmol/L) and high K+-induced contractions, likewise verapamil. In rabbit aorta preparation, M. champaca relaxed phenylephrine (1 μmol/L) and high K+-induced contractions similar to verapamil. Conclusion: M. champaca possesses spasmolytic, airways relaxant and vasodilator actions mediated perhaps due to blocking of Ca2+ channels, hence validating its therapeutic usage in diarrhea, asthma and hypertension.
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