| ORIGINAL ARTICLE |
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| Year : 2018 | Volume
: 11
| Issue : 3 | Page : 209-213 |
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Evaluating therapeutic potential of coriander seeds and leaves (Coriandrum sativum L.) to mitigate carbon tetrachloride-induced hepatotoxicity in rabbits
Muhammad Jawad Iqbal1, Masood Sadiq Butt1, Aamir Shehzad1, Muhammad Asghar2
1 National Institute of Food, Science & Technology, Faculty of Food, Nutrition and Home Sciences, University of Agriculture, Faisalabad, Pakistan
2 Department of Biochemistry, University of Agriculture, Faisalabad, Pakistan
Correspondence Address:
Muhammad Jawad Iqbal
National Institute of Food, Science & Technology, Faculty of Food, Nutrition and Home Sciences, University of Agriculture, Faisalabad
Pakistan
 Source of Support: None, Conflict of Interest: None  | 2 |
DOI: 10.4103/1995-7645.228435
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Objective: To evaluate the hepatic and renal protective potential of coriander seeds and leaves using animal feed model. Methods: Coriander seeds- and leaves-based sauces were administrated to normal (Study I) and carbon tetrachloride (2 mL/kg B.W.)-induced hepatotoxic rabbits (Study II). Hepatic and renal biomarkers like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, superoxide dismutase and catalase were measured. Results: Coriander leaves-based sauce exerted more decline (P<0.05) in serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase levels in the study II as 18.32%, 19.91% and 21.24%, respectively. While, hepatic superoxide dismutase and catalase levels were raised significantly (P<0.05) in both studies. Renal parameters also depicted positive impact by the provision of developed sauces. Conclusions: Coriander seeds and leaves based sauces are effective in alleviating the hepato/renal toxicity. The hepatoprotective effect of coriander leaves is more pronounced as compared to coriander seeds.
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