Figure 4: Photomicrographs of sections of hippocampal DG region showing normal molecular (M), granular cell (G) and pleomorphic layers (P) in the control group (A) and prominent nissl granules in (B), and large polyhydral cells (C). In AD model, reduced thickness of granular cell layer, marked vacuolation of disorganized cells (dashed arrows), and multiple shrunken cells with pyknotic nuclei (arrows) are noted (D). Chromatolysis of (G) cells (dashed arrows) (E) and multiple SP (arrows) and NFT (dashed arrows) are dispersed (F). Signs of degenerative changes decreased with PE administration (G-I) more than with EA treatment (J, K, L). DG: dentate gyrus; AD: Alzheimer; NFT: neurofibrillar tangles; SP: senile plaques; PE: pomergrantae peel extract; EA: ellagic acid (A, D, G, Ix H&E ×400), (B, E, H, Kx cresyl violet×400), (C, F, I, Lx Silver×400).