Figure 2: Photomicrographs of sections of hippocampal CA3 region showing normal poly-morphic (PO), pyramidal (PY) and molecular cell layers (MO) in the control group (A) and well defined distribution of nissl granules in (PY) cells (B). Silver stain showing normal pyramidal cells (C). In AD, apparent decreased thickness of the (PY) layer, pyramidal cells are shrunk with pyknotic nuclei (arrows), with vacuolated cytoplasm and areas devoid of cells are also revealed (D). Marked chromatolysis of PY cells (E), NFT (thin arrows) and (SP) (thick arrows) are prominent (F). In rats treated with PE, most of pyramidal cells of CA3 show normal structure (G), restored nissel granules (H) and less NFT and SP are noted (I). In groups treated with AD+EA, frequent apoptotic cells (arrows) are noted (J), chromatolysis of pyramidal cells (K) and persistent NFT and SP are still noted (L). AD: Alzheimer, NFT: neurofibrillar tangles, SP, senile plaques, PE: pomergrantae peel extract, EA: ellagic acid, (A, D, G, Jx H&E×400), (B, EH, Kx Cresyl violet ×400), (C, F, I, Lx Silver×400).