Figure 3: Multiple sequence alignment between the fragments of Culex theileri flavirus RdRp domain of NS5 proteins and structurally solved homologous NS5 proteins from flaviviruses PDB codes of the RdRp domains are: 2HFZ (WNV); 4HDG (JEV); 4K6M (JEV-SA-14); 5JJS (DENV-3); 5WZ3 (ZIKV). Blue and green bars below the alignment indicate deletions and insertions in the CTFV RdRp sequences. Cyan arrows mark the CTFV RdRp sites under selective pressure. Labelled grey bars mark the conserved viral RdRp catalytic motifs. The red line shows the position of the “Middle finger” subdomain. Sequence position numbering refers to 4HDG structure.