Figure 6: Therapeutic effect of P. daemia on ultra-structural alterations induced by ATDs. A: Electron micrograph of liver from control rat showed regular appearance of mitochondria (M) and cytoplasmic density (2 550×). B: ATDs exposure caused cellular damage with cytoplasmic vacuolation (V), mitochondrial degeneration, randomly scattered endoplasmic reticulum (ER) and glycogen (G) (4 000×). C: Liver cells of rats treated with ATDs and P. daemia at 200 mg/kg dose showed normal nucleus, well-fenestrated mitochondrion, well distributed endoplasmic reticulum, dense evenly distributed cytoplasm with lesser vacuolation (1 550×). D: Liver cells of rats treated with ATDs and silymarine at 50 mg/kg showed almost normal appearance with minimal cellular deterioration (2 550×).