Figure 1: Activation of curcumin-induced chloride currents and inhibition of the currents by the chloride channel blockers DIDS in Mcf-7 cells. (A & B) Cells were held at 0 mV and then stepped in sequence to ±80, ±40 and 0 mV repeatedly. Curcumin activated a chloride current which was inhibited by 100 μmol/L DIDS. (C) Traces of background currents recorded in the isotonic solution (Iso); (D)Traces of curcumin-induced currents. (E) Current traces showing inhibition of curcumin-activated currents by DIDS. Data in (B) are mean ±SE of Mcf-7 cells. *P< 0.05, **P< 0.01.