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  Indian J Med Microbiol
 

Figure 2: Representative light microphotographs from the striatum of mice (H & E, × 400). (A) Vehicle: normal neurons (N). (B) Rotenone: numerous pyknotic (arrow) and apoptotic (arrowhead) nuclei, vacuolation of neuropil (V) and congested capillaries (R). (C) Rotenone + misoprostol 10 μ g/kg: still pyknotic (arrow) and apoptotic (arrowhead) nuclei, vacuolation of neuropil (V). (D) Rotenone + misoprostol 100 μ g/kg: few pyknotic (arrow) and apoptotic neurons (arrowhead) with vacuolation (V). (E) Rotenone + misoprostol 1 000 μ g/kg: very few pyknotic (arrow), apoptotic nuclei (arrowhead) and congested capillaries (R).

Figure 2: Representative light microphotographs from the striatum of mice (H & E, × 400).
(A) Vehicle: normal neurons (N). (B) Rotenone: numerous pyknotic (arrow) and apoptotic (arrowhead) nuclei, vacuolation of neuropil (V) and congested capillaries (R). (C) Rotenone + misoprostol 10 μ g/kg: still pyknotic (arrow) and apoptotic (arrowhead) nuclei, vacuolation of neuropil (V). (D) Rotenone + misoprostol 100 μ g/kg: few pyknotic (arrow) and apoptotic neurons (arrowhead) with vacuolation (V). (E) Rotenone + misoprostol 1 000 μ g/kg: very few pyknotic (arrow), apoptotic nuclei (arrowhead) and congested capillaries (R).