Asian Pacific Journal of Tropical Medicine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 12  |  Issue : 2  |  Page : 79--86

Insecticide susceptibility status and resistance mechanism of Anopheles cracens Sallum and Peyton and Anopheles maculatus Theobald (Family: Culicidae) from knowlesi malaria endemic areas in Peninsular Malaysia


Ahmad Rohani1, Abdul Rahman Aidil Azahary2, Ke-Xin Yu3, Mohamed Nor Zurainee5, Wan Mohamad Ali Wan Najdah1, Han Lim Lee1 
1 Medical Entomology Unit, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
2 Medical Entomology Unit, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur; Department of Parasitology, University of Malaya, Kuala Lumpur, Malaysia
3 Faculty of Health and Life Sciences, Management and Science University, 40100 Shah Alam, Selangor, Malaysia

Correspondence Address:
Ahmad Rohani
Medical Entomology Unit, Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia
Malaysia

Objective: To assess the insecticide susceptibility status of Anopheles cracens (An. cracens) and Anopheles maculatus (An. maculatus) from knowlesi malaria endemic areas in Peninsular Malaysia towards DDT, malathion and deltamethrin and to determine the resistance mechanism involved. Methods: Adult and larval mosquitos were collected for surveillance. Susceptibility status of Anopheles was determined using the standard WHO adult bioassay, larval bioassay and biochemical enzyme assay. Results: WHO adult bioassay results indicated An. cracens collected from Kampung Sungai Ular, Pahang was resistant towards 4% DDT, while An. maculatus collected from Kampung Sokor, Kelantan and Kampung Sungai Lui, Selangor exhibited resistance towards 4% DDT. However, the enzyme activity profiles varied according to strains and species. The resistance ratio of larval bioassay, showed that all strains and species tested were susceptible to malathion and temephos. Conclusions: Since only a few anopheline strains exhibited low level of insecticide resistance towards malathion, DDT and temephos. These insecticides are still considered effective for vector control program towards An. cracens and An. maculatus.


How to cite this article:
Rohani A, Aidil Azahary AR, Yu KX, Zurainee MN, Wan Najdah WM, Lee HL. Insecticide susceptibility status and resistance mechanism of Anopheles cracens Sallum and Peyton and Anopheles maculatus Theobald (Family: Culicidae) from knowlesi malaria endemic areas in Peninsular Malaysia.Asian Pac J Trop Med 2019;12:79-86


How to cite this URL:
Rohani A, Aidil Azahary AR, Yu KX, Zurainee MN, Wan Najdah WM, Lee HL. Insecticide susceptibility status and resistance mechanism of Anopheles cracens Sallum and Peyton and Anopheles maculatus Theobald (Family: Culicidae) from knowlesi malaria endemic areas in Peninsular Malaysia. Asian Pac J Trop Med [serial online] 2019 [cited 2019 Apr 20 ];12:79-86
Available from: http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=2;spage=79;epage=86;aulast=Rohani;type=0