Asian Pacific Journal of Tropical Medicine

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 11  |  Issue : 4  |  Page : 292--296

Pharmacological basis for the medicinal use of Michelia champaca in gut, airways and cardiovascular disorders


Fatima Saqib1, Zubia Mushtaq1, Khalid Hussain Janbaz1, Imran Imran1, Saikat Deawnjee2, Muhammad Zia-Ul-Haq3, Lorena Dima4 
1 Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
2 Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
3 Office of Research, Innovation and Commercialization, Lahore College for Women University, Lahore 54600, Pakistan
4 Faculty of Medicine, Transilvania University of Brasov, Romania

Correspondence Address:
Muhammad Zia-Ul-Haq
Senior Manager Office of Research, Innovation and Commercialization, Lahore College for Women University, Lahore 54600
Pakistan

Objective: To discover the mechanism behind ameliorative effects of Michelia champaca (M. champaca) in gastrointestinal, respiratory and cardiovascular disorders. Methods: Anti- spasmodic potential was evaluated by trying the M. champaca extract (aqueous:ethanolic) on rabbit aorta, trachea and jejunum in vitro. Isotonic and isometric transducers coupled with Power Lab data acquisition system was used to record the responses of isolated tissues. Results: M. champaca extract relaxed the spontaneous and high K+ (80 mmol/L)-induced contractions of isolated jejunum preparation of rabbit showing a Ca2+ channel blocking mechanism. Moreover, extract shifted calcium concentration response curves towards right like standard calcium channel blocker verapamil. In rabbit tracheal preparation, M. champaca relaxed both carbachol (1 1 μmol/L) and high K+-induced contractions, likewise verapamil. In rabbit aorta preparation, M. champaca relaxed phenylephrine (1 μmol/L) and high K+-induced contractions similar to verapamil. Conclusion: M. champaca possesses spasmolytic, airways relaxant and vasodilator actions mediated perhaps due to blocking of Ca2+ channels, hence validating its therapeutic usage in diarrhea, asthma and hypertension.


How to cite this article:
Saqib F, Mushtaq Z, Janbaz KH, Imran I, Deawnjee S, Zia-Ul-Haq M, Dima L. Pharmacological basis for the medicinal use of Michelia champaca in gut, airways and cardiovascular disorders.Asian Pac J Trop Med 2018;11:292-296


How to cite this URL:
Saqib F, Mushtaq Z, Janbaz KH, Imran I, Deawnjee S, Zia-Ul-Haq M, Dima L. Pharmacological basis for the medicinal use of Michelia champaca in gut, airways and cardiovascular disorders. Asian Pac J Trop Med [serial online] 2018 [cited 2019 Dec 9 ];11:292-296
Available from: http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=4;spage=292;epage=296;aulast=Saqib;type=0