Asian Pacific Journal of Tropical Medicine

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 11  |  Issue : 1  |  Page : 78--81

Expression of fibronectin and MMP-3 and its significance in the patients with ankylosing spondylitis


Jun-Ling Zhu, Jian-Yao Zhou, Tao Hou, Jian-Zhi Zhao, Guo-Fang Wang, Xiao-Wei Han 
 Department of Rheumatology, Shaoxing Central Hospital, Zhejiang Province (312030), China

Correspondence Address:
Jun-Ling Zhu
Shaoxing Central Hospital, No 1, Huayu Road, Keqiao District, Department of Rheumatology, Zhejiang Province (312030)
China

Objective: To observe the expression and significance of fibronectin and metalloproteinase-3 (MMP-3) in patients with ankylosing spondylitis (AS). Methods: A total of 30 AS patients in our hospital and 30 healthy volunteers were selected in our study. Fibronectin and MMP-3 were measured and compared between these two groups. The AS group received sulfasalazine 2 g daily for 3 months. Bath ankylosing spondylitis disease activity index, bath ankylosing spondylitis functional index, bath ankylosing spondylitis metrology index, erythrocyte sedimentation rate and C-reactive protein were compared before and after treatment. Pearson's linear-correlation analysis was used to determine relationships between parameters. Results: Totally 28 patients in the AS group completed the study. Fibronectin and MMP-3 in peripheral blood of AS patients were evidently higher than that in the normal control group (P<0.05). After treated by sulfasalazine, the level of expressing Fibronectin and MMP-3 significantly decreased compared with baseline values (P<0.05). Pearson's linear-correlation analysis showed that serum fibronectin and MMP-3 level had a positive correlation with bath ankylosing spondylitis disease activity index global assessment, spine pain, night pain, general pain, erythrocyte sedimentation rate and C-reactive protein (P<0.05). Conclusions: The expression of fibronectin and MMP-3 in AS patients were significantly higher than that in the normal control group, and they all decreased significantly after treatment. It indicated that both fibronectin and MMP-3 were correlated closely with the onset of AS.


How to cite this article:
Zhu JL, Zhou JY, Hou T, Zhao JZ, Wang GF, Han XW. Expression of fibronectin and MMP-3 and its significance in the patients with ankylosing spondylitis.Asian Pac J Trop Med 2018;11:78-81


How to cite this URL:
Zhu JL, Zhou JY, Hou T, Zhao JZ, Wang GF, Han XW. Expression of fibronectin and MMP-3 and its significance in the patients with ankylosing spondylitis. Asian Pac J Trop Med [serial online] 2018 [cited 2020 Feb 22 ];11:78-81
Available from: http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=1;spage=78;epage=81;aulast=Zhu;type=0