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REVIEW ARTICLE
Year : 2020  |  Volume : 13  |  Issue : 4  |  Page : 143-151

Crimean-Congo hemorrhagic fever: etiology, diagnosis, management and potential alternative therapy


1 Department of Pharmacology, Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan
2 Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan
3 Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Pakistan

Correspondence Address:
Mohammad Saleem
Department of Pharmacology, Punjab University College of Pharmacy, University of the Punjab, Lahore
Pakistan
Muhammad Furqan Akhtar
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus
Pakistan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-7645.280221

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Crimean-Congo hemorrhagic fever (CCHF) virus belongs to the genus Nairovirus and family Bunyaviridae. CCHF is a tickborne disease that has mostly been reported from Asia, Africa and Europe. Early diagnosis of CCHF is essential for patient care and preventing its spread to normal individuals. Treatment of CCHF is mostly limited to the use of ribavirin and palliative care. The practice of using interferon and vaccines has also been proved to be ineffective and unsafe. A search for an effective alternative treatment of the CCHF still continues. Therefore, the current review focusses on the cause, prevalence, mode of transmission, pathophysiology, signs, symptoms, diagnostic features and treatment options of CCHF. This review also highlights the possible alternative therapy in the form of antiviral medicinal plants which are effective against viral hemorrhagic fever. These medicinal plants have shown convincing evidence for their activities against different viral hemorrhagic fevers and may be used alone or in combination with existing therapies to achieve an optimum therapeutic response.


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