Impact Factor 2018: 1.772 (@Clarivate Analytics)
5-Year Impact Factor: 1.772 (@Clarivate Analytics)
  • Users Online: 589
  • Print this page
  • Email this page
REVIEW ARTICLE
Year : 2020  |  Volume : 13  |  Issue : 3  |  Page : 107-114

Mapping the high burden areas of cholera in Nepal for potential use of oral cholera vaccine: An analysis of data from publications and routine surveillance systems


1 International Vaccine Institute (IVI), Seoul, Republic of Korea
2 Epidemiology and Disease Control Division, Department of Health Services, Ministry of Health and Population, Kathmandu, Nepal

Correspondence Address:
Chulwoo Rhee
International Vaccine Institute (IVI), Seoul
Republic of Korea
Login to access the Email id

Source of Support: This work was supported by the Governments of Korea, Sweden, India, and Bill and Melinda Gates Foundation (#OPP52797), Conflict of Interest: None


DOI: 10.4103/1995-7645.278095

Get Permissions

Objective: To assess the extent of existing published evidence on cholera and to characterize the epidemiologic data of cholera in Nepal. Methods: We conducted a literature scoping review by summarizing published literature reporting on cholera in Nepal from January 1946 to March 2019 in online databases: MEDLINE, Embase, Cochrane, and Global Health. Additionally, we reviewed national surveillance data on clinically diagnosed and laboratory confirmed cholera reported by the Ministry of Health and Population. Results: Most of the published studies were conducted predominantly in Kathmandu Valley during the rainy season; however, outbreaks have been reported in other parts of Nepal including Terai, Hilly and Mountain regions. Our literature review exhibited that all age groups were affected by cholera, but particularly children and young adults were at-risk age groups in Nepal. Vibrio cholerae serogroup O1, biotype El Tor, serotype Ogawa has been predominantly isolated with an emergence of resistant strains since 1996. Two mass vaccination campaigns using oral cholera vaccines were conducted: Rautahat district in 2014 and Banke district in 2017. Conclusions: Capacity building for a nation wide systematic cholera surveillance with rapid and reliable diagnosis is needed to better estimate the burden of cholera and identify geographically at-risk areas associated with the disease in Nepal. It is essential for developing an adequate policy on oral cholera vaccine introduction and effective water, sanitation and hygiene interventions.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1035    
    Printed27    
    Emailed0    
    PDF Downloaded143    
    Comments [Add]    
    Cited by others 1    

Recommend this journal