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ORIGINAL ARTICLE
Year : 2019  |  Volume : 12  |  Issue : 3  |  Page : 137-141

X-linked Toll-like receptor 7 polymorphism associated with susceptibility to Chikungunya Fever


Laboratorio de Fisiopatología, Centro de Medicina Experimental, IVIC, Apartado 21827, Caracas 1020A, Venezuela

Correspondence Address:
Mercedes Fernández-Mestre
Laboratorio de Fisiopatología, Centro de Medicina Experimental, IVIC, Apartado 21827, Caracas 1020A
Venezuela
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-7645.254940

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Objective: To investigate the association between TLR3 and TLR7 polymorphisms with susceptibility and clinical manifestations of Chikungunya Fever. Methods: A total of 177 individuals were studied: 73 patients with a confirmed diagnosis for Chikungunya virus and 104 non-infected individuals. Polymorphisms were determined by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: Our analysis showed an increased CC genotype frequency of the TLR7 rs3853839 polymorphism in male patients compared to control (29% versus 2%, respectively; OR=20.69; 95 % CI= 2.55-167.36; P<0.001). Furthermore, arthritis (acute and chronic) was frequently found in CC male patients. On the contrary, 65% of CG carriers were no-infected males (29% versus 65%, respectively; OR=0.23, 95% CI=0.48-3.04; P=0.002). Finally, we observed a higher frequency of lymphopenia in CG male patients (CG=666.86±233.77, GG=1,314.27±752.29 cells/mm3, P=0.047). Conclusions: Our results suggest the TLR7 rs3853839 polymorphism is associated with lymphopenia and increased susceptibility to Chikungunya Fever in males.


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