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ORIGINAL ARTICLE
Year : 2018  |  Volume : 11  |  Issue : 8  |  Page : 467-472

Protective effect of Ocimum sanctum Linn. leaf extract on ethanol withdrawal syndrome in Wistar rats


1 Department of Pharmacy, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh India, Pin code 173234, india
2 School of Pharmaceutical Sciences, Sholini University, Solan, Himachal Pradesh India, Pin Code 173229, india
3 Department of Pharmacology, SPPSPTM, SVKM’S NMIMS University, Mumbai, Maharashtra, Pin code 400 056, India
4 Department of BT and BI, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh India, Pin code 173234, India

Correspondence Address:
G L Gupta
Department of Pharmacology, SPPSPTM, SVKM-S NMIMS University, Mumbai, Maharashtra
India
Gopal Singh Bisht
Department of BT and BI, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-7645.240082

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Objective: To evaluate the effects of Oscimum sanctum L (O. sanctum), an important medicinal herb, on alcohol withdrawal syndrome in Wistar rats. Methods: Liquid diet with 7.2%, v/v ethanol was administered to the rats for 21 d. Control group animals received sucrose as an isocaloric liquid diet. After alcohol withdrawal, rats were examined at 6th and 24th hour for major withdrawal signs that included anxiety and hyper locomotor activity. Ethanol withdrawal anxiety was tested using elevated plus maze, light and dark model; the hyper locomotor activity using actophotometer. O. sanctum leaf extract (100, 200 and 300 mg/kg, oral) and diazepam (2 mg/kg, i.p) were administered to the treatment group animals 30 min before alcohol withdrawal estimation. Drug treatment was also given 30 min before the second observation at 24th hour. On the last day of the protocol, rats were sacrificed by cervical dislocation liver, kidney and brain were isolated and preserved in formalin for further histopathological examination. Results: Findings from the present study revealed that O. Sanctum leaf extract treatment at doses 100, 200 and 300 mg/kg, oral had a significant protective effect on signs and symptoms of ethanol withdrawal in alcohol-dependent rats. However, no remarkable pathological and microscopic alterations were observed in histopathological examination. Conclusions:O. sanctum seems to be an active drug for the treatment of alcohol abstinence syndrome.


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