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ORIGINAL ARTICLE
Year : 2018  |  Volume : 11  |  Issue : 6  |  Page : 376-380

Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) polymorphism as a genetic marker of cerebral malaria in Thai population


1 Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand; Department of Medical Laboratory Technology, University of Medical Technology, Yangon 11012, Myanmar
2 Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
3 Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan
4 Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University; Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand

Correspondence Address:
Dr. Pornlada Nuchnoi
Department of Clinical Microscopy, Faculty of Medical Technology, Mahidol University, Bangkok 10700
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-7645.234765

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Objective: To know whether the effect of interferon-induced protein with tetratricopeptide repeats (IFIT) 1 polymorphism influences the susceptibility of cerebral malaria outcome. Methods: Case-control association study was performed among 314 Thai patients (110 with cerebral malaria and 204 with uncomplicated malaria) infected with Plasmodium falciparum. Genotyping for five tag-single nucleotide polymorphisms of IFIT1 was performed by endpoint genotyping. Results: Genotype frequencies of all tag-SNPs (single nucleotide polymorphisms) showed no association with malaria outcome. However, C allele of rs11203109 was associated with the protection from cerebral malaria (OR=0.62, 95% CI=0.38-0.99, P=0.048). Two single nucleotide polymorphisms (rs5786868 and rs57941432) were in linkage disequilibrium with rs11203109. Conclusions: This suggests that our associated single nucleotide polymorphism (rs11203109) might be a genetic marker of cerebral malaria progression in the Thai population.


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