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ORIGINAL ARTICLE
Year : 2018  |  Volume : 11  |  Issue : 4  |  Page : 292-296

Pharmacological basis for the medicinal use of Michelia champaca in gut, airways and cardiovascular disorders


1 Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
2 Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
3 Office of Research, Innovation and Commercialization, Lahore College for Women University, Lahore 54600, Pakistan
4 Faculty of Medicine, Transilvania University of Brasov, Romania

Correspondence Address:
Muhammad Zia-Ul-Haq
Senior Manager Office of Research, Innovation and Commercialization, Lahore College for Women University, Lahore 54600
Pakistan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-7645.231470

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Objective: To discover the mechanism behind ameliorative effects of Michelia champaca (M. champaca) in gastrointestinal, respiratory and cardiovascular disorders. Methods: Anti- spasmodic potential was evaluated by trying the M. champaca extract (aqueous:ethanolic) on rabbit aorta, trachea and jejunum in vitro. Isotonic and isometric transducers coupled with Power Lab data acquisition system was used to record the responses of isolated tissues. Results: M. champaca extract relaxed the spontaneous and high K+ (80 mmol/L)-induced contractions of isolated jejunum preparation of rabbit showing a Ca2+ channel blocking mechanism. Moreover, extract shifted calcium concentration response curves towards right like standard calcium channel blocker verapamil. In rabbit tracheal preparation, M. champaca relaxed both carbachol (1 1 μmol/L) and high K+-induced contractions, likewise verapamil. In rabbit aorta preparation, M. champaca relaxed phenylephrine (1 μmol/L) and high K+-induced contractions similar to verapamil. Conclusion: M. champaca possesses spasmolytic, airways relaxant and vasodilator actions mediated perhaps due to blocking of Ca2+ channels, hence validating its therapeutic usage in diarrhea, asthma and hypertension.


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