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ORIGINAL ARTICLE
Year : 2018  |  Volume : 11  |  Issue : 1  |  Page : 48-52

Effects of aqueous extract of Notobasis syriaca on lipopolysaccharide-induced inflammation in rats


1 Triangle Research & Development Center, Kfar-Qari, 30026 ; Formerly: Institute of applied Research, Box 437, Shefa-Amr, 20200, Israel
2 Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
3 Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences; Department of Nursing, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

Correspondence Address:
Abed N Azab
School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B 653, Beer-Sheva 84105
Israel
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-7645.223533

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Objective: To investigate the effects of a dry aqueous extract of Notobasis syriaca (N. syriaca) on lipopolysaccharide (LPS)-induced inflammation in rats. Methods: Rats were fed the dried extract [500 mg/(kgod)] for three consecutive days and then were intraperitoneally injected with LPS (1 mg/kg). Two hours after LPS injection, rats were sacrificed and blood and brain regions were collected. Inflammatory mediators’ levels in plasma and homogenates of brain regions were determined by ELISA. Results: Pretreatment with the N. syriaca extract resulted in significant anti-inflammatory effects (P<0.05), including: i) attenuated LPS-induced hypothermia; ii) decreased hypothalamus and hippocampus prostaglandin E2 levels in the LPS- treated rats; and, iii) reduced hypothalamus and hippocampus interleukin-6 and tumor necrosis factor- α levels in the LPS-treated rats. Conclusions: These results suggest that N. syriaca possesses anti-inflammatory properties. Thus, it is possible that long-term consumption of this plant may result in beneficial pharmacological effects.


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