5-Year Impact Factor: 1.225 (@Thomson Reuters)
Impact Factor 2016: 0.925 (@Thomson Reuters)
  • Users Online: 216
  • Print this page
  • Email this page
REVIEW ARTICLE
Year : 2018  |  Volume : 11  |  Issue : 1  |  Page : 1-8

An updated systematic review of Zika virus-linked complications


1 Centre for Applied Molecular Biology, 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab; Genome Centre for Molecular Based Diagnostics and Research Centre, Cl-25 Block B Al-Sudais Plaza Abdalian Cooperative Society, Lahore, Pakistan
2 Centre for Applied Molecular Biology, 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan
3 Centre for Applied Molecular Biology, 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab; Genome Centre for Molecular Based Diagnostics and Research Centre, Cl-25 Block B Al-Sudais Plaza Abdalian Cooperative Society, Lahore; Hazara University, Mansehra, Pakistan

Correspondence Address:
Amjad Ali
Centre for Applied Molecular Biology, University of the Punjab, Lahore-53700
Pakistan
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-7645.223527

Get Permissions

Objective: To determine the breadth of Zika virus (ZIKV)-associated brain anomalies in neonates and adults. Methods: Systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement using electronic databases ScienceDirect, Pubmed, Medline, Scopus, and Global Health Library. Only those research articles, case studies, case-control studies, case-cohort studies, cross-sectional studies, and organizational survey reports were included in the study that reported any fetal outcomes for pregnant women who had infected with ZIKV during the gestational period and ZIKV-related neurological complications in adults as well. Results: Out of total 72 retrieved articles, 50 met the inclusion criteria. We estimated a significant increase in incidence of neural abnormalities such as Guillain-Barre syndrome and microcephaly in the regions that are experiencing ZIKV outbreaks. Other neurological malformations found in ZIKV patients include hydrancephaly/hydrops fetalis, myasthenia gravis, meningoencephalitis and myelitis. Conclusion: Our systematic analysis provides the broad spectrum of neurological malformations in ZIKV infected patients and these data further support the causal link of ZIKV with neurological disorders.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed429    
    Printed27    
    Emailed0    
    PDF Downloaded129    
    Comments [Add]    

Recommend this journal