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ORIGINAL ARTICLE
Year : 2018  |  Volume : 11  |  Issue : 10  |  Page : 570-575

Anti-schistosomal activities of Echinops kebericho Mesfin root and Hagenia abyssinica (Bruce) J.F Gmel flower part crude extracts in Swiss albino mice


1 School of Medical Laboratory Sciences, Jimma University, P.O. Box: 378, Jimma, Ethiopia
2 School of Veterinary Medicine, Jimma University, P.O. Box: 378, Jimma, Ethiopia
3 School of Pharmacy, Jimma University, P.O. Box: 378, Jimma, Ethiopia

Correspondence Address:
Yonas Alemu
School of Medical Laboratory Sciences, Jimma University, Jimma, P.O. Box: 378
Ethiopia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-7645.244517

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Objective: To evaluate the in vivo antischistosomal activities of the crude extracts of Echinops kebericho Mesfin (E. kebericho) root and Hagenia abyssinica (Bruce) J.F. Gmel (H. abyssinica) flower. Methods: Mice were infected with (150 ± 10) Schistosoma mansoni cercariae by paddling technique. Crude extracts were administered orally for five consecutive days at doses of 300, 600 and 1 200 mg/kg/day along with 200 mg/kg/day praziquantel and 3% tween 80 given as a control. Results: E. kebericho root extract showed a statistically significant (P < 0.05) reduction in fecal egg count of 64.44%, 42.96% & 26.82% and worm burden of 65.71%, 47.86% & 31.43% at treatment doses of 1 200 mg/kg/day, 600 mg/kg/day and 300 mg/kg/day, respectively. Similarly, H. abyssinica flower extracts showed a significant (P < 0.05) reduction in fecal egg count up to 84.57%, 77.06% & 63.89% and worm burden of 91.43%, 81.43% & 70.71% at a respective dose levels. In addition, a significant (P < 0.05) reduction in liver granuloma score was observed in all H. abyssinica administered dose groups and E. kebericho at 1 200 mg/kg/day dose group as compared to infected untreated control group. Conclusions: H. abyssinica and E. kebericho crude extracts show a promising antischistosomal activity.


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