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ORIGINAL ARTICLE
Year : 2018  |  Volume : 11  |  Issue : 10  |  Page : 562-569

Efficacy of voriconazole on leishmaniasis by Leishmania major: An in vitro and in vivo study


1 Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
2 Department of Parasitology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Correspondence Address:
Ahmad Oryan
Department of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1995-7645.244516

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Objective: To appraise the activity of voriconazole against Leishmania major (L. major) in vitro and its effectiveness on wound regeneration in cutaneous leishmaniasis in BALB/c mice. Methods: The IC50 of voriconazole against promastigotes and intra-macrophage amastigotes of L. major was investigated in vitro. The in vivo study was performed by treating the L. major infected BALB/c mice. When the wounds appeared in the base of tail, treatment was started by administration of 30 mg/kg voriconazole for 28 consecutive days orally. Results: The IC50 of voriconazole against promastigotes and intra-macrophage amastigotes were 0.74 and 0.89 ģĢ, respectively. Voriconazole decreased lipid peroxidation and IL-6 level. Histopathological findings indicated accelerated healing in the voriconazole treated group compared to other groups. Conclusions: Our results demonstrate that voriconazole can be an option in treating the cutaneous leishmaniasis by L. major.


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